Wing (John) Chan, M.D.
Phone: 402.559.7684
Email:
jchan@unmc.edu
Interests:
Hematopathology
Lymphoma biology and Pathogenesis
Development and Refinement of Molecular Assays
Research
My main interest is in the pathobiology and pathogenesis of lymphomas. In collaboration with the National
Cancer Institute, Stanford University, British Columbia Cancer Agency, SWOG and a number of European
Institutions, we are examining the gene expression profiles of B-cell non-Hodgkin's lymphoma (NHL).
Our data have shown that it is possible to delineate clinicopathologic subtypes of NHL by gene expression
profiling. These early data also indicate that it is possible to sub-divide well-defined categories of NHL
into further sub-types that may have different clinical behaviors. Our long-term goal is to identify genes
which are critical in determining the clinical and biologic behavior of the different sub-types of lymphoma.
We will build molecular prognosticators based on our findings. Some of these genes may be important targets
for the development of novel therapy for lymphoma. We are also working on the amplification of total mRNA
isolated from a limited number of Reed-Sternberg cells in order to study the gene expression profile of
Hodgkin Lymphoma.
I am also actively engaged in the development and refinement of molecular assays in the diagnosis of
lymphomas and leukemias, in the detection of minimal residual disease after treatment and in delineating
the relationship between various types of malignant lymphomas.
Education and Training
MBBS, M.D.; University of Hong Kong
Residency, University of Chicago, 1975-1979
Immunology Research, University of Chicago, 1979- 1980
Board Certification: AP, CP, HP
National Activities
Editorial Board, American Journal of Clinical Pathology
Editorial Board, American Journal of Pathology
NCI Sponsored Lymphoma/Leukemia Molecular Profiling Project: Co-chair of Coordinating Committee
and Chair of Pathology Committee
